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湖南省副省长陈飞调研亚热带生态所丁仲礼副院长调研亚热带生态所重点实验室研究所大门稻米镉污染控制技术研究与示范应用项目鉴定会现场外国专家特聘研究员Dr. Davey Jones教授访问亚热带生态所Karen Beauchemin教授作特邀学术报告亚热带生态所与华中农大签署科技教育合作协议在京集中教学研究生开展徒步活动研究生志愿者参与“保卫蓝天活动”开展红色教育主题党日活动开展红色教育主题党日活动——体验红军走过的路
    段叶辉
  • 姓 名:段叶辉 性    别:
    职 务:
    职 称:副研究员 学 历:博士
    电 话:0731-84619767 通迅地址:湖南省长沙市芙蓉区远大二路644号
    传 真:0731-84612685 邮政编码:410125
    电子邮件:duanyehui@isa.ac.cn
  • 简历
  • 2010年6月毕业于青海大学草业科学专业,获农学学士学位;2013年6月毕业于中国科学院大学动物营养与饲料科学专业,主修猪脂肪酸营养方向,获农学硕士学位;2018年1月毕业于中国科学院大学生态学专业,主修猪氨基酸营养与肌肉生长及肉品质调控方向,获理学博士学位。毕业后在中国科学院亚热带农业生态研究所从事畜禽健康养殖研究工作,现任副研究员。

    目前主要从事单胃动物氨基酸营养和肌肉生长与脂肪代谢调控的研究。目前主持国家自然基金青年基金1项、广西省自然科学青年基金1项、广东省动物营养调控重点实验室开放课题1项、企业横向课题1项,先后参加国家自然科学基金联合基金项目、国家973课题、国家自然科学基金面上项目、国家重点研发计划和中科院人才计划项目等课题,现以第一作者/通讯作者发表SCI论文30余篇。

  • 承担科研项目
  • 主持项目:

    2019.3-2022.2 广西科技计划项目“β-羟基-β-甲基丁酸调节巴马香猪脂肪代谢的分子机制”(2018JJB130239)

    2019.1-2021.12 国家自然科学青年基金“HMB通过Akt-FoxO3a信号通路缓解免疫应激仔猪肌肉蛋白质降解的机制研究”(31802077)

    2018.5-2019.5 广东省动物营养调控重点实验室开放课题“亮氨酸代谢物对免疫应激仔猪肌肉蛋白质降解的作用机制研究”(DWYYTK-18KF002)

    2018.4-2021.4 企业横向课题“茶粉在香猪生产养殖中的应用关键技术”

    参加项目:

    2020/01-2023/12 国家自然科学基金联合基金项目“沙子岭猪优良肉质性状形成的分子机制及营养调控”(U19A200048)

    2017/01-2019/12 国家自然科学青年基金“色氨酸影响猪胎盘滋养层细胞抗氧化应激损伤机制的研究”(31601953)。

    2016/1-2019/12 中科院青年创新促进会项目“肌细胞高效利用氮营养素的机制研究”(2015326)。

    2013/1-2017/12 国家973项目专题“肌肉组织对氮营养素的差异性沉积规律”(2013CB127305)。

    2014/1-2014/12 国家自然科学基金面上项目“mTORC1介导的亮氨酸调节猪肌肉和脂肪的能量平衡与互作机制”(31372325)。

    2011/1-2013/12 国家自然科学基金青年基金项目“肌肉细胞因子—白介素15对猪肌内脂肪细胞代谢的调控及其机制研究”(31001015)。

  • 代表论著
  • 发表英文论文目录:

    1.Duan YH#, Zhong YZ#, Song Bo, Zheng CB, Xu K, Kong XF, Li FN*. Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes. Aging (Albany NY), 2019, 11: 11922-11936.

    2.Duan YH#, Zhong YZ#, Xiao H#, Zheng CB, Song B, Wang WL, Guo QP, Li YY, Han H, Gao J, Xu K, Li TJ, Yin YL, Li FN, Yin J, Kong XF. Gut microbiota mediates the protective effects of dietary beta-hydroxy-beta-methylbutyrate (HMB) against obesity induced by high-fat diets. FASEB Journal, 2019, 33(9): 10019-10033.

    3.Song B#, Zhong YZ#, Zheng CB, Li FN, Duan YH*, Deng JP*. Propionate alleviates high fat diet-induced lipid dysmetabolism by modulating gut microbiota in mice. J Appl Microbiol, 2019, 127: 1546-1555.

    4.Duan YH#, Zheng CB#, Zhong YZ, et al. Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation via increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge. Food & Function, 2019, 10(8): 5152-5165.

    5.Duan YH, Li FN, Song B, Zheng CB, Zhong YZ, Xu K, Kong XF, Yin YL, Wang WC, Shu G. β-hydroxy-β-methyl butyrate, but not α-ketoisocaproate and excess leucine, stimulates skeletal muscle protein metabolism in growing pigs fed low-protein diets. Journal of Functional Foods, 2019, 52: 34-42.

    6.Zhong YZ#, Zeng LM#, Deng JP, Duan YH*, Li FN. β-hydroxy-β-methylbutyrate (HMB) improves mitochondrial function in myocytes through pathways involving PPARβ/δ and CDK4. Nutrition, 2019, 60: 217-226.

    7.Zhong YZ#, Song B#, Zheng CB, Li FN, Kong XF, Duan YH*, Deng JP*. α-ketoisocaproate and β-hydroxy-β-methyl butyrate regulates fatty acid composition and lipid metabolism in skeletal muscle of growing pigs. Journal of Animal Physiology and Animal Nutrition, 2019, 103: 846-857.

    8.Duan YH, Zhao Y, Zhu Q, Cai Q, Li H, Yin YL, Wang Z, Kong XF. Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini-pigs. Journal of the Science of Food and Agriculture, 2019, 99: 2132-2139.

    9.Duan YH, Li FN*, Guo QP, Wang WL, Zhang LY, Wen CY, Chen XA, Yin YL, β-hydroxy-β-methyl butyrate Is More Potent Than Leucine in Inhibiting Starvation-Induced Protein Degradation in C2C12 Myotubes, Journal of Agricultural and Food Chemistry, 2018, 66(1): 170-176

    10.Duan YH, Li FN*, Guo QP, Wang WL, Zhang LY, Wen CY, Chen XA, Yin YL, Branched-Chain Amino Acid Ratios Modulate Lipid Metabolism in Adipose Tissues of Growing Pigs, Journal of Function Foods, 2018, 40: 614-624

    11.Duan YH, Zhang LY, Li FN, Guo QP, Long CM, Yin YL, Kong XF, Peng MJ, and Wang WC. β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs. Food & Function, 2018, 9, 4836-4846

    12.Duan YH, Li FN, Wen CY, Wang WL, Guo QP, Li YH, and Yin YL. Branched-chain amino acid ratios in low-protein diets regulate the free amino acid profile and the expression of hepatic fatty acid metabolism-related genes in growing pigs [J]. Journal of Animal Physiology and Animal Nutrition, 2018, 102: e43-e51.

    13.Duan YH, Tan BE, Li JJ, Liao P, Huang B, Li FN, Xiao H, Liu YH, Yin YL. Optimal branched-chain amino acid improve cell proliferation and protein metabolism of porcine enterocytes in vivo and in vitro. Nutrition, 2018, 54: 173-181

    14.Duan YH, Zhao Y, Zhu Q, Cai QL, Li HW, Yin YL, Wang ZB, Kong, XF. Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini-pigs. Journal of The Science of Food and Agriculture, 2018, DOI: 10.1002/jsfa.9405

    15.Duan YH, Li FN, Tan BE, Yao K, Yin YL. Metabolic Control of Myofibers: Promising Therapeutic Target. Obesity Reviews, 2017, 18 (6): 647-659.

    16.Duan YH, Guo QP, Wen CY, Wang WL, Li YH, Tan BE, Li FN and Yin YL. Interleukin-15 in obesity and metabolic dysfunction: current understanding and future perspectives [J]. Obesity Reviews, 2017, 18 (10): 1147-1158.

    17.Duan YH, Zeng LM, Li FN, Wang WL, Li YH, Guo QP, Ji YJ, Tan BE, and Yin YL. Effect of branched-chain amino acid ratio on the proliferation, differentiation and the expression levels of key regulators involved in protein metabolism of myocytes. Nutrition, 2017, 36: 8-16.

    18.Duan YH, Li YH, Wang WL, Guo QP, Wen CY, and Yin YL. Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched-chain amino acid ratios. Oncotarget, 2017, 8: 107011-107021.

    19.Wang ZY, Duan YH (Co-first author), Li FN, Yang BC, Zhang JX, and Hou SZ. Dietary supplementation with Lonicera macranthoides leaf powder enhances growth performance and muscle growth of Chinese Tibetan pigs. Livestock Science, 2017, 206: 1-8.

    20.Wang ZY, Yuan DX, Duan YH (Corresponding author), Li SJ, Hou SZ. Key factors involved in obesity development [J]. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2017, https://doi.org/10.1007/s40519-017-0428-3.

    21.Duan YH, Li FN, Yin YL. Is Leucine Restriction/Deprivation an Inducer of Adipose Browning? [J]. Trends in Pharmacological Sciences, 2016, 37 (10): 807-808.

    22.Yao K, Duan YH (Co-first author), Li FN, Tan BE, Hou YQ, Wu GY, Yin YL. Leucine in obesity: Therapeutic Prospects. Trends in Pharmacological Sciences, 2016, 37 (8): 714-727.

    23.Duan YH, Guo QP, Wen CY, Wang WL, Li YH, Tan BE, Li FN and Yin YL. Free amino acid profile and expression of genes related to protein metabolism in skeletal muscle of growing pigs fed low-protein diets supplemented with branched-chain amino acids. Journal of Agricultural and Food Chemistry, 2016, 64 (49): 9390-9400.

    24.Duan YH, Zeng LM, Li FN, Li YH, Tan BE, Ji YJ, Kong XF, Tang YL, Zhang YZ, Yin YL. Effects of different dietary branched-chain amino acid ratio on growth performance and serum amino acid pool of growing pigs. Journal of Animal Science, 2016, 94 (7): 129-134.

    25.Duan YH, Li FN, Li YH, Tang YL, Kong XF, Feng ZM, Anthony TG, Watford M, Hou YQ, Wu GY, Yin YL. The role of leucine and its metabolites in protein and energy metabolism. Amino Acids, 2016, 48 (1): 41-51.

    26.Duan YH, Duan YM, Li FN, Li YH, Guo QP, Ji YJ, Tan BE, Li TJ, and Yin YL. Effects of supplementation with branched-chain amino acids to low-protein diets on expression of genes related to lipid metabolism in skeletal muscle of growing pigs. Amino Acids, 2016, 48 (9):2131-2144.

    27.Duan YH, Li FN, Liu HN, Li YH, Liu YY, Kong XF, Zhang YZ, Deng D, Tang YL, Feng ZM, Wu GY, and Yin YL. Nutritional and regulatory roles of leucine in muscle growth and fat reduction. Frontiers in Bioscience-Landmark, 2015, 20, 796-813.

    28.Duan YH, Li FN, Tan KR, Liu HN, Li YH, Liu YY, Kong XF, Tang YL, Wu GY, Yin YL. Key mediators of intracellular amino acids signaling to mTORC1 activation. Amino acids, 2015, 47 (5): 857-867.

    29.Li FN, Duan YH (Co-first author), Li YH, Tang YL, Geng MM, Oladele OA, Kim SW, and Yin YL. Effect of dietary n-6 to n-3 PUFAs ratio on fatty acid composition, free amino acid profile and gene expression of transporters in finishing pigs. British Journal of Nutrition, 2015, 113 (5): 739-748.

    30.He X, Duan YH (Co-first author), Yao K, Li FN, Hou YQ, Wu GY, Yin YL. Beta-hydroxy-beta-methylbutyrate, mitochondrial biogenesis, and skeletal muscle health. Amino Acids, 2016, 48 (3): 653-664.

    31.Duan YH, Li FN, Tan BE, Lin BB, Kong XF, Li YH, Yin YL. Myokine Interleukin-15 expression profile is different in suckling and in weaning piglets. Animal Nutrition, 2015, 1: 30-35.

    32.Li FN, Duan YH (Co-first author), Li YH, Tang YL, Geng MM, Oladele OA, Kim SW, and Yin YL*. Effect of Dietary N-6 to N-3 PUFAs Ratio on Fatty Acid Composition, Free Amino Acid Profile and Gene Expression of Transporters in Finishing Pigs. British Journal of Nutrition, 2015, 113(5): 739-748.

    33.Duan YH, Li FN*, Li L, Fan J, Sun X, and Yin Y*. N-6: N-3 PUFA Ratio Is Involved in Regulating Lipid Metabolism and Inflammation in Pigs. British Journal of Nutrition, 2014, 111: 445-451.

    34.Li YH, Li FN, Chen S, Duan YH, Guo QP, Wang WL, Wen CY, and Yin YL. Protein-restricted diet regulates lipid and energy metabolism in skeletal muscle of growing pigs. Journal of Agricultural and Food Chemistry, 2016, 64: 9412-9420.

    35.Li YH, Wei HK, Li FN, Duan YH, Guo QP, Yin YL. Effects of low-protein diets supplemented with branched-chain amino acid on lipid metabolism in white adipose tissue of piglets. Journal of Agricultural and Food Chemistry, 2017, 65: 2839-2848.

    36.Li YH, Li FN, Duan YH, Guo QP, Wang WL, Wen CY, Huang XG, and Yin YL. The protein and energy metabolic response of skeletal muscle to the low-protein diets in growing pigs. Journal of Agricultural and Food Chemistry, 2017, 65: 8544-8551.

    37.Jiang Q, Liu G, Wang XQ, Hou YQ, Duan YH, Wu GY, Yin YL, and Yao K. Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells. Oncotarget, 2017. 8: 74820-74835.

    38.Li FN, Li YH, Duan YH, Hu CA, Tang YL, and Yin YL. Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue. Cytokine & Growth Factor Reviews, 2017, 33: 73-82.

    39.Li, FN, Li, YH, Duan, YH, Tang, YL, Anthony, T, Watford, M, Yin Y. Proteomic Analysis Reveals Cross-Talk of Adipocytes and Myotubes in Co-Culture. FASEB JOURNAL, 2015, 29: 742.5.

    40.Li FN, Li YH, Tan BE, Wang J, Duan YH, Guo QP, Liu YY, Kong XF, Li TJ, Tang YL, and Yin YL. Alteration of inflammatory cytokines, energy metabolic regulators, and muscle fiber type in the skeletal muscle of postweaning piglets. Journal of Animal Science, 2016, 94: 1064-1072.

    41.Li YH, Wei HK, Li FN, Kim SW, Wen CY, Duan YH, Guo QP, Wang WL, Liu HN, and Yin YL. Regulation in free amino acid profile and protein synthesis pathway of growing pig skeletal muscles by low-protein diets for different time periods. Journal of Animal Science, 2016, 94 (12): 5192-5205.

    42. Jiang Q, He LQ, Hou YQ, Chen JS, Duan YH, Deng D, Wu GY, Yin YL, and Yao K. Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells. Amino Acids, 2016, 48 (9): 2179-2188.

    43.Liu YY, Kong XF, Li FN, Tan BE, Li YH, Duan YH, Yin YL, He J, Hu CAA, Blachier F, Wu GY. Co-dependence of the genotype and the dietary protein intake on the gene expression of amino acid/peptide transporters in porcine skeletal muscle. Amino Acids, 2016, 48 (1): 75-90.

    44.Wu F, Xiong X, Yang H, Yao K , Duan YH, Wang X, Tan B, Li T, Xiao L, Hou Y, Wu GY. Expression of proteins in intestinal middle villus epithelial cells of weaning piglets. Frontiers in Bioscience-Landmark, 2017, 22: 539-557.

    45.Li YH, Li FN, Wu L, Wei HK, Liu YY, Li TJ, Tan BE, Kong XF, Yao K, Chen S, Wu F, Duan YH, and Yin YL. Effects of dietary protein restriction on muscle fiber characteristics and mTORC1 pathway in the skeletal muscle of growing-finishing pigs. Journal of Animal Science and Biotechnology, 2016, 7 (1): 47.

    46.Liu YY, Li FN, Kong XF, Tan BE, Li YH, Duan YH, Blachier F, Hu CAA, and Yin YL. Signaling pathways related to protein synthesis and amino acid concentration in pig skeletal muscles depend on the dietary protein level, genotype and developmental stages. PLoS One, 2015, 10 (9): e0138277.

    47. Li YH, Li FN, Wu L, Liu YY, Li TJ, Tan BE, Kong XF, Wu F, Duan YH, Oladele OA, and Yin YL. Reduced dietary protein level influences the free amino acid and gene expression profiles of selected amino acid transceptors in skeletal muscle of growing pigs. Journal of Animal Physiology and Animal Nutrition, 2017, 101: 96-104.

    48.Li YH, Wei HK, Li FN, Chen S, Duan YH, Guo QP, Liu YY, and Yin YL. Supplementation of branched-chain amino acids in protein-restricted diets modulates the expression levels of amino acid transporters and energy metabolism associated regulators in the adipose tissue of growing pigs. Animal Nutrition, 2016, 2: 24-32.

    发表中文论文目录:

    1.段叶辉, 李颖慧, 欧晋平, 刘惠知, 郭志森, 陈晓安, 贺轩阳. 液态活性乳酸菌在“母子一体化”养殖上的应用效果研究. 湖南畜牧兽医, 2015, (6): 13-15.

    2.段叶辉, 李凤娜, 李丽立, 印遇龙. n-6/n-3多不饱和脂肪酸比例对机体生理功能的调节. 天然产物研究与开发, 2014, 26, 626-631.

    3.段叶辉, 喻春明, 王延周, 朱娟娟, 熊和平. 苎麻生物活性物质的作用及其研究利用现状. 天然产物研究与开发, 2014, 26: 152-158.

    4.段叶辉, 印遇龙, 李丽立, 李凤娜, 杨焕胜, 孙效名. n-3 PUFAs对脂质代谢和炎症-免疫的调节机制. 生物技术通报, 2012, 3: 28-34.

    5.段叶辉, 李丽立, 张彬, 邓世林, 王升平, 范觉鑫, 刘志强, 刘旭. 不同途径补硒对放养鸡体内硒含量和胴体性状的影响. 中国畜牧兽医,2011, 38(10): 5-8.

    6.王勇飞, 段叶辉 (通讯作者), 夏连喜, 陈福华. 重组猪表皮生长因子对早期断奶仔猪生产性能的影响. 动物营养学报, 2014,26 ( 12):3787-3792.

    7.邓敦, 段叶辉 (通讯作者), 姚康, 李铁军, 印遇龙. 饲粮中添加苹果渣对妊娠母猪粪便及繁殖性能的影响. 动物营养学报, 2015, 27 (2): 535-540.

    8.宋博#, 尹杰#, 郑昌炳, 仲银召, 李凤娜, 段叶辉*, 印遇龙*, 邓近平*. 低蛋白日粮在畜禽生产中的应用研究进展. 中国饲料, 2020(3): 8-15.

    9.郑昌炳, 段叶辉, 邓近平, 印遇龙. 氨基酸调控猪肉品质的研究进展. 动物营养学报, 2020, 32(6): 1-6.

    10.郭秋平, 胡魏, 文超越, 王文龙, 段叶辉, 李颖慧, 李凤娜, 黄瑞林. 动物黄脂病的形成因素及其可能的机制. 动物营养学报, 2018, 30: 421-427.

    11.文超越, 段叶辉, 李颖慧, 郭秋平, 孔祥峰, 李凤娜. 能量感应网络AMPK/SIRT1/PGC-lα对骨骼肌纤维类型转化调节. 动物营养学报, 2016, 1: 57-63.

    12.陈家顺, 吴飞, 段叶辉, 李建军, 蒋谦, 李欢, 黄牛, 田军权, 印遇龙, 姚康. 饲粮添加α-酮戊二酸对仔猪氮及钙、磷代谢的影响. 动物营养学报, 2016, 28 (7): 2154-2161.

    13.郭秋平, 文超越, 王文龙, 段叶辉, 李颖慧, 李凤娜. 肌纤维类型转化的分子信号通路及其营养调控进展. 动物营养学报, 2017, 6: 1836-1842.

    14.郭秋平, 文超越, 王文龙, 段叶辉, 李颖慧, 孔祥峰, 李凤娜. 低聚木糖对仔猪生长性能、肌肉组织营养成分含量及肌纤维类型组成的影响. 动物营养学报, 2017, 8: 2769-2776.

    15.王文龙, 文超越, 郭秋平, 段叶辉, 李颖慧, 何善平, 李凤娜. 绿原酸的生物活性及其作用机制. 动物营养学报, 2017. 29 (7): 2220-2227.

    16.文超越, 李勇, 邢伟刚, 段叶辉, 李颖慧, 张宇喆, 李凤娜. 饲粮减少矿物元素对育肥猪生长性能、肉品质、血清生化指标以及骨骼肌矿物元素含量的影响. 动物营养学报, 2017, 29 (2): 597-604.

    17.许友卿, 张青红, 李颖慧, 段叶辉, 胡毅, 丁兆坤. 饲料中添加杜仲叶粉对青鱼生长和组织免疫相关基因表达的影响研究. 农业现代化研究, 2015, 36 (6):1074-1079.

    出版著作目录:

    1.印遇龙 主编. 段叶辉 参编. 猪营养代谢与调控研究. 长沙:湖南科学技术出版社, 2011, 3.

    2.肖定福 主编. 段叶辉 参编. 山地肉牛生态养殖实用技术. 长沙:湖南科学技术出版社, 2013, 8.

    3.李丽立 主编. 段叶辉 参编. 乡村生态养鸭实用技术. 长沙:湖南科学技术出版社, 2013, 11.

    专利:

    1.段叶辉; 李凤娜; 仲银召; 印遇龙; 孔祥峰; 李铁军; 谭碧娥; 徐康; 尹杰; 龙次民; β-羟基-β甲基丁酸系物质在制备缓解断奶仔猪免疫应激及促肌肉生长饲料中的应用, 2019-3-21, 中国, 201910216545 .9.

    2.韩慧; 尹杰; 李铁军; 段叶辉; 刘泽民; 印遇龙; D-半乳糖诱导的断奶仔猪慢性氧化应激模型的构建方法, 2019-1-18, 中国, 201910048963 .1.

    获奖:

    1.段叶辉,中国畜牧兽医学会动物营养学分会第三届青年学者讲坛优胜奖,中国畜牧兽医学会动物营养学分会,2019

    2.段叶辉,中国畜牧兽医学会动物营养学分会帝斯曼缤纷科技奖——动物营养科学青年学者优胜奖, 中国畜牧兽医学会动物营养学分会,2018

    学术交流:

    1.段叶辉,支链氨基酸及其代谢产物调控猪营养代谢的机制,第四届中国畜牧兽医学会“青年拔尖人才”学术论坛,广州,2020-1-8至2020-1-10

    2.段叶辉,支链氨基酸及其代谢产物调控猪蛋白质和脂质代谢的机制,第三届中国畜牧兽医学会动物营养学分会青年学者讲坛,北京,2019-11-26至2019-11-28

    3.段叶辉,支链氨基酸及其代谢物在猪低蛋白日粮中的应用及机制研究,第三届“农业生态前沿青年论坛”,长沙,2018-11-9至2018-11-11

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