谭碧娥

姓 名:谭碧娥 性 别:女

职 务:

职 称:研究员 学 历:博士

电 话:(86)-731-84619706 通迅地址:湖南省长沙市芙蓉区远大二路644号

传 真:(86)-731-84612685 邮政编码:410125

电子邮件:bietan@isa.ac.cn

简历

研究员,博士,主要从事仔猪肠道发育和营养调控研究。1979年出生,湖南宁乡人。2001年7月毕业于湖南农业大学动物医学专业,获农学学士学位;2010年7月毕业于中国科学院亚热带农业生态所动物生态营养专业,获理学博士学位;分别于2008年2月至2009年1月在美国Texas A&M University以及2016年12月至2017年12月在美国University of California, Davis进行访问研究。先后主持国家自然科学基金青年1项、面上项目2项,国家科技支撑计划专题1项,973项目子课题1项,以及其他省部级项目4项。近年来以第一/通讯作者发表SCI和CSCD收录论文40多篇,其中SCI收录论文30多篇,参编著作4部,申请发明专利2项。获国家自然科学奖二等奖(排名第2)、中华农业科技奖一等奖(排名第5)、湖南省自然科学奖一等奖(排名第2)、中科院广州分院优秀青年科学家奖、中国科学院院长优秀奖。入选科技部创新人才推进计划(中青年科技创新领军人才)、中国科学院青年创新促进会会员和湖湘青年科技创新创业平台培养对象;目前兼任中国畜牧兽医学会动物营养学分会理事。

承担科研项目

2017.1-2020.12国家自然科学基金面上项目“AMPK和mTORC1介导氨基酸调控仔猪小肠黏膜能量利用与损伤修复”(31672433)

2014.1-2017.12国家自然科学基金面上项目“SNAT2介导的猪小肠氨基酸感应机制研究”(31372326)

2015.1-2017.12 国家973计划专题“小肠黏膜结构、功能与氮营养素吸收利用”(2013CB127302)

2014.1-2016.12国家科技部科技支撑计划项目“设施养殖饲料非接触快速溯源与在线检定关键技术设备研发”(2014BAD08B11)

2014.9-2017.8 湖湘青年科技创新创业平台培养对象自主选题项目“猪肠道氨基酸利用和细胞代谢研究”

2014.1-2017.12 中国科学院青年创新促进会会员资助项目“猪肠道氨基酸营养感应”(2014336)

2015.1-2016.12 湖南省科技项目应用基础研究计划项目“杜仲黄酮调控仔猪肠道氧化损伤修复的研究(2015JC3126)”

2011.1-2013.12国家自然科学青年基金“精氨酸转运和代谢调控猪肠上皮细胞生长的分子机制研究”(31001016)

2010.11-2013.12中科院院长奖获得者科研启动专项资金“精氨酸调控仔猪肠道健康的分子机制研究”

代表论著

1.Tan BE, Yin YL. Environmental sustainability analysis and nutritional strategies of animal production in China. Annual Review of Animal Biosciences, 2017, 5

2.Xiao H, Wu MM, Shao FY, Guan GP, Huang B, Tan BE*(Corresponding Author), Yin YL. N-Acetyl-L-cysteine Protects the Enterocyte against Oxidative Damage by Modulation of Mitochondrial Function. Mediators of Inflammation, 2016, Article ID 8364279.

3.Ren W, Wang K, Yin J, Chen S, Liu G, Tan B*(Corresponding Author), Wu G, Bazer FW, Peng Y and Yin Y*. Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective. Frontiers in Immunology, 2016, 7:503.

4.Ren W, Yin J, Xiao H, Chen S, Liu G, Tan B*(Corresponding Author), Li N, Peng Y, Li T*, Zeng B, Li W, Wei H, Yin Z, Wu G, Hardwidge P, Yin Y*. Intestinal microbiota derived-GABA mediates interleukin-17 expression during enterotoxigenic Escherichia coli (ETEC) infection. Frontiers in Immunology, 2016, 7:685.

5.Ren WK, Yin J, Chen S, Duan JL, Liu G*, Li TJ, Li N, Peng Y, Tan BE*(Corresponding Author), Yin YL*. Proteome analysis for the global proteins in the jejunum tissues of enterotoxigenic Escherichia coli-infected piglets. Sci Rep. 2016, 6:25640. doi: 10.1038/srep25640.

6.Ren WK. Liu G, Yin J, Tan BE*(Corresponding Author), Wu GY, Bazer FW, Peng Y, Yin YL*. Amino-acid transporters in T-cell activation and differentiation. Cell Death and Disease (2016) 7, e; doi:10.1038/cddis.2016.222

7.Hussain T, Tan BE*(Corresponding Author), Yin YL, Blachier F, Tossou MCB, Rahu N. Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Oxidative medicine and cellular longevity 2016(4):1-9

8.Ren WK, Chen S, Zhang LW, Liu G, Hussain T, Xiao H, Yin J, Duan JL, Tan BE*(Corresponding Author), Wu GY, Bazer FW, Yin YL*. Interferon tau affects mouse intestinal microbiota and expression of IL-17. Mediators of Inflammation, 2016, Article ID 2839232

9.Huang B, Xiao DF, Tan BE*(Corresponding Author), Xiao H, Wang J, Yin J, Duan JL, Huang RL, Yang CB, Yin YL. Chitosan Oligosaccharide Reduces Intestinal Inflammation That Involves Calcium-Sensing Receptor (CaSR) Activation in Lipopolysaccharide (LPS)-Challenged Piglets, Journal of Agricultural and Food Chemistry, 2016, 64(1): 245-252

10.Wang J, Tan BE*(Corresponding Author), Li GR, Xiao H, Huang B, Zhang MH, Yin YL. Polyamine metabolism in the intestine of piglets is altered by weaning and proline supplementation. Journal of Animal Science, 2016, 94:423–428

11.Tan BE, Guan GP, Yao K, Fang J, Liu YY, Li TJ, Sun H, Yin YL. Profiles of amino acids released from different nitrogen composited diets in different segments of the gastrointestinal tract of pigs. Journal of Animal Science, 2016, 94:276–278.

12.Guan GP, Tan BE*(Corresponding Author), Yao K, Fang J, He GZ, Li TJ, Sun H, Yin YL. Dynamic profiles of amino acids released from different nitrogen composited diets in the jejunum of pigs. Journal of Animal Science, 2016, 94:283-285

13.Hussain T, Tan BE*(Corresponding Author), Liu G, Oladele OA, Rahu N, Tossou MC, Yin YL. Health-Promoting Properties of Eucommia Ulmoids:A Review. Evidence-Based Complementary and Alternative Medicine, 2016, 2016(12): 1-9

14.Wang J, Zeng LM, Tan BE*(Corresponding Author), Li GR, Huang B, Xiong X, Li FN, Kong XF, Liu G, Yin YL. Developmental changes in intercellular junctions and Kv channels in the intestine of piglets during the suckling and post-weaning periods. Journal of Animal Science and Biotechnology, 2016, 7(1): 1-10

15.Tan BE, Xiao H, Xiong X, Wang J, Li GR, Yin YL*, Huang B, Hou YQ, Wu GY. L-Arginine improves DNA synthesis in LPS-challenged enterocytes. Frontiers in Bioscience, 2015, 20: 989-1003

16.Xiao H, Wu MM, Tan BE*(Corresponding Author), Li TJ, Ren WK, Yin J, Wang J, He QH, Yin YL*, Hou YQ. Metabolic profiles in the response to supplementation with compositeantimicrobial peptides in piglets challenged with deoxynivalenol. Journal of Animal Science, 2015, 93(3): 1114-1123

17.Xiao H, Shao FY, Wu MM, Ren WK, Xiong X, Tan BE*(Corresponding Author), Yin YL. The application of antimicrobial peptides as growth and health promotersin swine nutrition. Journal of Animal Science and Biotechnology, 2015, 6: 19

18.Tan BE, Xiao H, Li FN, Zeng LM, Yin YL. The proles of mitochondrial respiration and glycolysis using extracellularux analysis in porcine enterocyte IPEC-J2. Animal Nutrition, 2015, 1(3): 239-243

19.Wang J, Li GR, Tan BE*(Corresponding Author), Xiong X, Kong XF, Xiao DF, Xu LW, Wu MM, Huang B, Kim SW, Yin YL. Oral administration of putrescine and proline during the suckling period improve epithelial restitution after early weaning in piglets. Journal of Animal Science, 2015, 93(4): 1679-1688

20.Li GR , Li JJ, Tan BE*(Corresponding Author), Wang J, Kong XF, Guan GP, Li FN, Yin YL. Characterization and regulation of the amino acid transporter SNAT2 in the small intestine of piglets. PLoS ONE, 2015, 10(6): e0128207

21.Xiao H, Wu MM, Shao FY, Huang B, Tan BE*(Corresponding Author), Yin YL. N-acetyl-L-cysteine (NAC) protects the enterocyte against oxidative damage by preserving mitochondrial function. Amino Acids, 2015, 47(8): 1681-1681

22.Guan GP, Tan BE*(Corresponding Author), Liu YY, Kong XF, Chen QL, He GZ, Fang J, Li JJ, Yin YL*. Apparent digestibility of crude protein, gross energy, gross ash andamino acids from four dietary protein sources in young pigs. Amino Acids, 2015, 47(8): 1682-1682

23.Tan BE, He GZ, Xiao H, Xiong X, Yin YL, Fang J. Alanyl-glutamine but not glycyl-glutamine improved the proliferation ofenterocytes as glutamine substitution in vitro.Amino Acids, 2015, 47(8): 1680-1681

24.Xiao H, Wu MM, Tan BE*(Corresponding Author), Yin YL*, Li TJ, Xiao DF, Li L. Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol : Ⅰ. Growth performance, immune function and antioxidation capacity. Journal of Animal Science, 2013, 91(10):4772-4780

25.Xiao H, Tan BE(Joint First Authors), Wu MM, Yin YL*, Li TJ, Yuan DX, Li L. Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function. Journal of Animal Science, 2013, 91(10):4750-4756

26.Zhang J, Yin YL*, Shu XG, Li TJ*, Li FN, Tan BE*(Corresponding Author), Wu ZL, Wu GY. Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets. Amino Acids, 2013, 45:1169–1177

27.Tan BE, Li XG, Yin YL, Wu ZL, Liu C, Tekwe CD, Wu GY. Regulatory roles for L-arginine in reducing white adipose tissue. Frontiers in Bioscience, 2012, 17: 2237-2246

28.Tan BE, Li XG, Wu GY, Kong XF, Liu ZQ, Li TJ, Yin YL. Dynamic changes in blood flow and oxygen consumption in the portal-drained viscera of growing pigs receiving acute administration of L-arginine. Amino Acids, 2012, 43:2481–2489

29.Tan BE, Liu ZQ, Tang WJ, Xu HJ, Kong XF, Li XG, Yao K, Gu WT, Shinzato I, Smith SB, Wu GY. Dietary arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. Journal of Nutritional Biochemistry, 2011, 22: 441-445.

30.Tan BE, Yin YL, Kong XF, Li P, Li XL, Gao HJ, Li XG, Huang RL, Wu GY. L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells. Amino Acids, 2010, 38: 1227-1235.

31.Tan BE, Yin YL, Liu ZQ, Xu HJ, Kong XF, Huang RL, Tang WJ, Shinzato I, Smith SB, Wu GY. Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino Acids, 2009, 37:169-175

32.Tan BE, Li XG, Kong XF, Huang RL, Ruan Z, Yao K, Deng ZY, Xie MY, Shinzato I, Yin YL, Wu GY. Dietary L-arginine supplementation enhances the immune status in early-weaned piglets. Amino Acids, 2009, 37:323-331.

33.贺光祖, 谭碧娥*(通讯作者), 肖昊, 印遇龙, 方俊. 肠道小肽吸收利用机制及其营养功能. 动物营养学报,2015, 27(4): 1047-1054

34.肖昊, 谭碧娥*(通讯作者), 吴苗苗, 邵方元, 印遇龙. mTOR 信号通路调节细胞能量代谢的机制. 中国科学: 生命科学, 2015, 45: 1124–1131. Xiao H, Tan B E, Wu M M, Shao F Y, Yin Y L. Regulatory mechanism of mTOR signaling pathway on cell energy metabolism. SCIENTIA SINICA Vitae, 2015, 45: 1124–1131, doi: 10.1360/N052015-00132

35.黄博, 胡佳宇, 吴苗苗, 肖昊, 张军, 谭碧娥*(通讯作者), 印遇龙. 猪胃肠道谷氨酸代谢及其对机体健康的影响. 动物营养学报,2015, 27(11): 3326-3331

36.李光燃, 谭碧娥*(通讯作者), 管桂萍, 印遇龙. 钠离子依赖性中性氨基酸转运载体2特性、表达调控及功能. 动物营养学报,2015, 27(11): 3338-3344

37.谭碧娥,印遇龙. 胃肠营养化学感应及其生理效应. 动物营养学报,2013, 25(2):231-241.

38.曾黎明,谭碧娥*(通讯作者),肖昊,印遇龙*,卢向阳,方俊. 氨基酸转运载体介导的氨基酸感应信号研究进展.中国科学·生命科学,2012, 42:699-708.

39.谭碧娥,李新国,孔祥峰,姚康,伍国耀,印遇龙. 精氨酸对早期断奶仔猪肠道生长、组织形态及IL-2基因表达水平的影响. 中国农业科学,2008,41(9):2783-2788.

40.谭碧娥,宾石玉,孔祥峰,褚武英,黄瑞林,李铁军,印遇龙. 不同淀粉来源日粮对断奶仔母猪内脏组织蛋白质合成的影响. 华北农学报,2007,22(3):188-192.

41.谭碧娥,何兴国,孔祥峰,褚武英,黄瑞林,李铁军,印遇龙. 不同碳水化合物对断奶仔公猪肠道微生物区系的影响. 动物营养学报,2007,19(4):316-320.

42.谭碧娥,宾石玉,孔祥峰, 褚武英,黄瑞林,李铁军,印遇龙. 不同日粮来源淀粉在断奶仔猪小肠不同部位消化及体外降解研究. 中国农业科学,2008,41(4):1172-1178.

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